Nifedipine is a potent calcium channel blocker and used as anti-hypertensive agent. The present study describes a simple, sensitive and rapid colorimetric method for determination of nifedipine in bulk and tablet dosage form. The proposed method is based on reduction of the nitro group of nifedipine to amino group by treatment with zinc dust and hydrochloric acid. The reduced molecule was diazotized with sodium nitrite and coupled with Bratton-Marshalls Reagent (N-1-naphthyl) ethylenediamine dihydrochloride). The produced azo dye was measured using colorimeter at 430 nm. The developed method was validated in terms of precision specificity and lineatity range. This method provides the faster and cost effective quality control tool for routine analysis of nifedipine in bulk and tablet dosage form.
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